Pacific Biosciences is based in the heart of Silicon Valley and provides sophisticated genomic sequencing and analysis systems that deliver invaluable insights for scientists who strive to resolve complex genetic challenges.  Harnessing advances in biochemistry, optics, nanofabrication, and more, PacBio developed Single Molecule, Real-Time (SMRT) Sequencing technology. This powerful technology enables real-time analysis of biomolecules with single-molecule resolution.

PacBio sequencing offers the most comprehensive view of genomes, transcriptomes, and epigenomes — including the full spectrum of genetic variation — by providing the longest average read lengths, highest consensus accuracy, and most uniform coverage of any sequencing technology on the market today. Ideal for de novo genome assembly and genetic variation characterization of humansanimals + plants, and microbes, this system features high-performance optics, automated liquid handling, and an intuitive, intelligent operating system.


PacBio's technology provides the most comprehensive view of genomes, transcriptomes, and epigenomes.


Achieve the highest consensus accuracy and uniform coverage for reference quality genomes in humans, plants, animals, and microbes.


Explore how epigenetic changes affect gene expression, host-pathogen interactions, environmental response, and more.




Accurately detect and uncover all variant types even in hard-to-reach regions of the genome.


Discover new genes, transcripts, and alternative splicing events with a complete view of transcript isoform diversity.



Long-read sequencing

Industry-leading accuracy with HiFi sequencing for complete views of genomes, epigenomes, and transcriptomes

Throughput to run up to 1,300 human HiFi genomes per year

Smart consumables for simple handling and less plastic waste

Powerful compute with Google Health DeepConsensus onboard

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Short-read sequencing

Greater level of sensitivity to detect rare variants

Reduced requirement for sequencing coverage depth versus SBS sequencers

Contiguous reads through homopolymer and difficult to sequence regions

Low duplication rate, no index hopping

Rapid conversion of existing P5/P7 libraries for sequencing on the Onso system

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Long-read sequencing

Long, accurate HiFi reads with DNA methylation direct from the instrument in every run

Supports a wide range of applications – targeted sequencing, RNA sequencing, and whole-genome sequencing

Throughput match for microbial genome sequencing, AAV vector sequencing, Iso-Seq, and more

Featured in hundreds of peer-reviewed publications

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HIFI Sequencing - Unlock Your Next Great Discovery

With HiFi sequencing you get the benefits of short reads and traditional long reads in one easy-to-use technology. Watch this short video to learn how HiFi sequencing is empowering scientists to strive for new breakthroughs.

HiFi reads let you accurately detect all types of variants, from single nucleotide to structural variants, with high precision and recall and phase haplotypes, even in hard-to-sequence regions of the genome.


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